Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 11/20 | 0.52 |
| ▸ | RPTOR | Q8N122 | 11/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 11/20 | 0.52 |
| ▸ | GPR6 | P46095 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141547 | 0.94 | MTOR (0.52) | MTORRPTORMLST8GPR6DRD4 | |
| SCHEMBL20156794 | 0.90 | MTOR (0.54) | MTORRPTORMLST8GPR6PKM | |
| SCHEMBL20156994 | 0.88 | KDM4E (0.54) | MTORRPTORMLST8DRD4KDM4E | |
| SCHEMBL20140323 | 0.88 | KDM4E (0.54) | MTORRPTORMLST8DRD4KDM4E | |
| SCHEMBL20140545 | 0.88 | MTOR (0.51) | MTORRPTORMLST8GPR6DRD4 | |
| SCHEMBL20140417 | 0.88 | MTOR (0.51) | MTORRPTORMLST8GPR6DRD4 | |
| SCHEMBL20157225 | 0.88 | MTOR (0.53) | MTORRPTORMLST8DRD4KDM4E | |
| SCHEMBL20140200 | 0.87 | MTOR (0.59) | MTORRPTORMLST8DRD4KDM4E | |
| SCHEMBL20140884 | 0.85 | MTOR (0.51) | MTORRPTORMLST8DRD4KDM4E | |
| SCHEMBL20139966 | 0.85 | MTOR (0.61) | MTORRPTORMLST8GPR6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |