Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157204 | 1.00 | MTOR (0.49) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20156980 | 1.00 | MTOR (0.49) | MTORRPTORMLST8GRM1CHRM4 | |
| Trifluoroacetic Acid SCHEMBL20139882 | 0.95 | MTOR (0.47) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20156955 | 0.93 | MTOR (0.48) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20140592 | 0.93 | MTOR (0.48) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20140650 | 0.93 | MTOR (0.48) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20140242 | 0.90 | MTOR (0.46) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20156876 | 0.90 | MTOR (0.44) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20156877 | 0.90 | MTOR (0.44) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20156856 | 0.90 | MTOR (0.44) | MTORRPTORMLST8GRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |