Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157236 | 0.89 | DRD4 (0.43) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20157079 | 0.87 | MTOR (0.50) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20157176 | 0.87 | MTOR (0.50) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20157087 | 0.87 | MTOR (0.50) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20157235 | 0.79 | DRD4 (0.47) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20157267 | 0.78 | DRD4 (0.52) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20139958 | 0.77 | NAMPT (0.53) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20140542 | 0.77 | DRD4 (0.50) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20141780 | 0.76 | DRD4 (0.46) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20129666 | 0.76 | MTOR (0.62) | DRD4DRD3DRD2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |