Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | BRD2 | P25440 | 2/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.31 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362229 | 0.88 | BRD4 (0.39) | BRD4MAPK14BRD2BRD3BRDT | |
| SCHEMBL21362230 | 0.88 | BRD4 (0.39) | BRD4MAPK14BRD2BRD3BRDT | |
| SCHEMBL21351854 | 0.79 | BRD4 (0.42) | BRD4MAPK14BRD2BRD3BRDT | |
| SCHEMBL20158054 | 0.78 | BRD4 (0.41) | BRD4MAPK14BRD2BRD3BRDT | |
| SCHEMBL21362189 | 0.77 | BRD4 (0.42) | BRD4MAPK14BRD2BRD3BRDT | |
| SCHEMBL21351853 | 0.76 | BRD4 (0.47) | BRD4MAPK14BRD2BRD3BRDT | |
| SCHEMBL21351950 | 0.74 | BRD4 (0.35) | BRD4MAPK14THRB | |
| SCHEMBL21351914 | 0.73 | BRD4 (0.41) | BRD4MAPK14BRD2BRD3BRDT | |
| SCHEMBL21362394 | 0.73 | BRD4 (0.39) | BRD4MAPK14THRB | |
| SCHEMBL21352125 | 0.72 | BRD4 (0.34) | BRD4MAPK14THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086605-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |