Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.46 |
| ▸ | ITGB6 | P18564 | 13/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 6/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141850 | 0.80 | ITGAV (0.57) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL20141424 | 0.80 | ITGAV (0.48) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL12807006 | 0.78 | ITGAV (0.58) | ITGAVITGB6ITGB3ITGB5 | |
| SCHEMBL21766819 | 0.77 | ITGAV (0.60) | ITGAVITGB6ITGB3ITGB5 | |
| SCHEMBL13833866 | 0.76 | ITGAV (0.56) | ITGAVITGB6ITGB3ITGB5 | |
| SCHEMBL30336058 | 0.76 | ITGAV (0.56) | ITGAVITGB6ITGB3ITGB5 | |
| SCHEMBL20142062 | 0.76 | ITGAV (0.56) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL26461918 | 0.76 | ITGAV (0.48) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL31444865 | 0.75 | ITGAV (0.48) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL20141425 | 0.75 | ITGAV (0.54) | ITGAVITGB6ITGB3ITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089355-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |