Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL20139757 | 0.95 | MTOR (0.50) | MTORRPTORMLST8HTR7POLB | |
| SCHEMBL20159286 | 0.92 | MTOR (0.51) | MTORRPTORMLST8HTR7POLB | |
| SCHEMBL20159115 | 0.90 | MTOR (0.55) | MTORRPTORMLST8HTR7POLB | |
| SCHEMBL20159024 | 0.89 | MTOR (0.64) | MTORRPTORMLST8HTR7POLB | |
| SCHEMBL20159011 | 0.87 | MTOR (0.44) | MTORRPTORMLST8HTR7POLB | |
| SCHEMBL20139298 | 0.86 | CHRM4 (0.58) | MTORRPTORMLST8CHRM4CHRM2 | |
| SCHEMBL20139300 | 0.86 | CHRM4 (0.58) | MTORRPTORMLST8CHRM4CHRM2 | |
| SCHEMBL20159007 | 0.85 | POLB (0.55) | MTORRPTORMLST8HTR7POLB | |
| SCHEMBL20159166 | 0.85 | POLB (0.55) | MTORRPTORMLST8HTR7POLB | |
| SCHEMBL20139877 | 0.83 | MTOR (0.64) | MTORRPTORMLST8HTR7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |