Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.40 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | STK36 | Q9NRP7 | 1/20 | 0.40 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20160421 | 0.88 | BRD4 (0.50) | BRD4BRD2BRD3BRDT | |
| SCHEMBL20160319 | 0.85 | BRD4 (0.40) | BRD4BRD2BRD3BRDT | |
| SCHEMBL20160343 | 0.85 | LRRK2 (0.43) | MAPK14BRD4BRD2BRD3BRDT | |
| SCHEMBL20160005 | 0.84 | BRD4 (0.39) | BRD4BRD2BRD3BRDT | |
| SCHEMBL20160094 | 0.84 | BRD4 (0.38) | MAPK14MAPK8BRD4BRD2BRD3 | |
| SCHEMBL20160232 | 0.83 | BRD4 (0.39) | BRD4BRD2BRD3BRDT | |
| SCHEMBL20160041 | 0.82 | BRD4 (0.39) | MAPK14BRD4BRD2BRD3BRDT | |
| SCHEMBL20160324 | 0.82 | BRD4 (0.44) | BRD4BRD2BRD3BRDT | |
| SCHEMBL20160344 | 0.81 | BRD4 (0.40) | BRD4BRD2BRD3BRDT | |
| SCHEMBL20160096 | 0.79 | BRD4 (0.48) | BRD4BRD2BRD3BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086585-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |