Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139760 | 0.85 | PDE5A (0.49) | PDE5AADORA3KCNH2 | |
| SCHEMBL21787180 | 0.83 | PDE5A (0.46) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140170 | 0.81 | PDE5A (0.51) | PDE5AADORA3KCNH2 | |
| SCHEMBL20141166 | 0.80 | PDE5A (0.50) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140370 | 0.80 | PDE5A (0.49) | PDE5AADORA3KCNH2 | |
| SCHEMBL20139731 | 0.79 | PDE5A (0.49) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140216 | 0.78 | PDE5A (0.50) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140292 | 0.77 | PDE5A (0.48) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140394 | 0.77 | PDE5A (0.48) | PDE5A | |
| SCHEMBL20140385 | 0.77 | PDE5A (0.52) | PDE5AADORA3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |