Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.83 |
| ▸ | TXK | P42681 | 14/20 | 0.83 |
| ▸ | ITK | Q08881 | 8/20 | 0.83 |
| ▸ | JAK3 | P52333 | 14/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20161942 | 0.91 | BTK (1.00) | BTKTXKITKJAK3 | |
| SCHEMBL20161947 | 0.88 | ITK (0.83) | BTKTXKITKJAK3 | |
| SCHEMBL24467279 | 0.88 | ITK (0.83) | BTKTXKITKJAK3 | |
| SCHEMBL24467340 | 0.86 | JAK3 (0.82) | BTKTXKITKJAK3 | |
| SCHEMBL24467289 | 0.83 | BTK (0.84) | BTKTXKITKJAK3 | |
| SCHEMBL20161689 | 0.82 | BTK (1.00) | BTKTXKITKJAK3 | |
| SCHEMBL20161917 | 0.82 | BTK (0.81) | BTKTXKITKJAK3 | |
| SCHEMBL20162003 | 0.81 | BTK (0.79) | BTKTXKITKJAK3 | |
| SCHEMBL20161893 | 0.81 | JAK3 (0.85) | BTKTXKITKJAK3 | |
| SCHEMBL20161488 | 0.80 | BTK (1.00) | BTKTXKITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089261-A2 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |