Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 10/20 | 0.35 |
| ▸ | TXK | P42681 | 13/20 | 0.34 |
| ▸ | ITK | Q08881 | 9/20 | 0.34 |
| ▸ | BTK | Q06187 | 7/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20161646 | 1.00 | SRC (0.35) | SRCJAK3TXKITKBTK | |
| SCHEMBL20161664 | 0.89 | JAK3 (0.36) | SRCJAK3TXKITKBTK | |
| SCHEMBL24476768 | 0.89 | JAK3 (0.36) | SRCJAK3TXKITKBTK | |
| SCHEMBL21610061 | 0.89 | JAK3 (0.36) | SRCJAK3TXKITKBTK | |
| SCHEMBL2033628 | 0.79 | — | — | |
| SCHEMBL23366022 | 0.79 | JAK3 (0.38) | SRCJAK3TXKITKBTK | |
| SCHEMBL25212730 | 0.78 | GAA (0.38) | GAATSHRMAPT | |
| SCHEMBL20892969 | 0.78 | SRC (0.45) | SRCJAK3BTKGAA | |
| SCHEMBL11931515 | 0.78 | SRC (0.45) | SRCJAK3BTKGAA | |
| SCHEMBL32667654 | 0.78 | SRC (0.45) | SRCJAK3BTKGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3534899-B1 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS INC (US) | 2022-06-01 | — | — | EP | disclosed |
| WO-2018089261-A2 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |