Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 11/20 | 0.83 |
| ▸ | JAK3 | P52333 | 11/20 | 0.67 |
| ▸ | TXK | P42681 | 14/20 | 0.65 |
| ▸ | BTK | Q06187 | 13/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24467224 | 0.90 | ITK (1.00) | ITKJAK3TXKBTK | |
| SCHEMBL20161436 | 0.90 | ITK (1.00) | ITKJAK3TXKBTK | |
| SCHEMBL27089733 | 0.86 | JAK3 (0.81) | ITKJAK3TXKBTK | |
| SCHEMBL20161935 | 0.86 | TXK (0.80) | ITKJAK3TXKBTK | |
| SCHEMBL24467335 | 0.81 | JAK3 (0.80) | ITKJAK3TXKBTK | |
| SCHEMBL20161678 | 0.80 | JAK3 (1.00) | ITKJAK3TXKBTK | |
| SCHEMBL24467300 | 0.80 | JAK3 (1.00) | ITKJAK3TXKBTK | |
| SCHEMBL24467325 | 0.80 | TXK (0.84) | ITKJAK3TXKBTK | |
| SCHEMBL20161470 | 0.80 | ITK (0.77) | ITKJAK3TXKBTK | |
| SCHEMBL24467258 | 0.79 | JAK3 (0.79) | ITKJAK3TXKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3534899-B1 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS INC (US) | 2022-06-01 | — | — | EP | disclosed |
| WO-2018089261-A2 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |