Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 14/20 | 0.49 |
| ▸ | DPP4 | P27487 | 13/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL20163990 | 1.00 | DPP8 (0.49) | DPP8DPP4DPP7DPP9FAP | |
| Trifluoroacetic Acid SCHEMBL20163991 | 1.00 | DPP8 (0.49) | DPP8DPP4DPP7DPP9FAP | |
| Trifluoroacetic Acid SCHEMBL20163996 | 0.87 | DPP8 (0.46) | DPP8DPP4DPP7DPP9 | |
| Trifluoroacetic Acid SCHEMBL20163994 | 0.87 | DPP8 (0.46) | DPP8DPP4DPP7DPP9 | |
| Trifluoroacetic Acid SCHEMBL20163995 | 0.87 | DPP8 (0.46) | DPP8DPP4DPP7DPP9 | |
| Trifluoroacetic Acid SCHEMBL14738473 | 0.80 | DPP8 (0.47) | DPP8DPP4DPP7 | |
| Trifluoroacetic Acid SCHEMBL6824315 | 0.77 | DPP8 (0.48) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL20163856 | 0.75 | DPP4 (0.38) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL20163854 | 0.75 | DPP4 (0.38) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL20163852 | 0.75 | DPP4 (0.38) | DPP8DPP4DPP7DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313397-B1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME (US) | 2020-11-25 | — | — | EP | disclosed |
| US-10221178-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME CORP. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20180141947-A1 | Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10221178-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3CA, PI4KA | DPP8 2397/4885DPP4 2117/4885DPP7 1804/4885 |
| US-20180141947-A1 | Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta | PIK3CD, PIK3CA, PI4KA | DPP8 2397/4885DPP4 2117/4885DPP7 1804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.