Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18138200 | 0.86 | JAK2 (0.53) | JAK2JAK3KDM4EALDH1A1HPGD | |
| SCHEMBL18132112 | 0.84 | JAK2 (0.71) | JAK2JAK3KDM4EALDH1A1 | |
| SCHEMBL3610664 | 0.84 | JAK2 (0.52) | JAK2JAK3 | |
| SCHEMBL18132129 | 0.84 | JAK2 (0.52) | JAK2JAK3 | |
| SCHEMBL3607833 | 0.80 | JAK2 (0.59) | JAK2JAK3 | |
| SCHEMBL24303585 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1THRBHPGD | |
| SCHEMBL30844879 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1THRBHPGD | |
| SCHEMBL28603330 | 0.78 | AURKA (0.49) | KDM4EALDH1A1THRBHPGD | |
| SCHEMBL18138214 | 0.78 | DYRK1A (0.47) | JAK2JAK3 | |
| SCHEMBL18132018 | 0.77 | JAK2 (0.56) | JAK2JAK3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280418-B1 | AZACARBAZOLE BTK INHIBITORS | MERCK SHARP & DOHME (US) | 2020-05-06 | — | — | EP | disclosed |
| US-20180141962-A1 | AZACARBAZOLE BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141962-A1 | AZACARBAZOLE BTK INHIBITORS | BTK, SYK, LYN | JAK2 6/4885JAK3 152/4885KDM4E 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.