SCHEMBL2016706 — predicted protein targets

Predicted protein targets (top 18)

	gene	UniProt	supporting neighbours	confidence
▸	ALDH1A1	P00352	2/20	0.43

▸	TSHR	P16473	2/20	0.43

▸	PIK3CD	O00329	2/20	0.42

▸	TDP1	Q9NUW8	2/20	0.41

▸	KDM4E	B2RXH2	1/20	0.41

▸	KMT2A	Q03164	3/20	0.38

▸	GPR6	P46095	1/20	0.37

▸	L3MBTL1	Q9Y468	3/20	0.36

▸	MAPT	P10636	2/20	0.36

▸	AKT1	P31749	1/20	0.35

▸	RAB9A	P51151	4/20	0.34

▸	NPC1	O15118	3/20	0.34

▸	ALOX12	P18054	2/20	0.34

▸	NCOA3	Q9Y6Q9	1/20	0.34

▸	SLC40A1	Q9NP59	1/20	0.33

▸	MEN1	O00255	1/20	0.33

▸	HSP90AA1	P07900	1/20	0.33

▸	THRB	P10828	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Trifluoroacetic Acid SCHEMBL2040822	0.95	PIK3CD (0.40)	ALDH1A1TSHRPIK3CDTDP1KDM4E
SCHEMBL2164038	0.90	PIK3CD (0.42)	ALDH1A1PIK3CDTDP1KDM4EL3MBTL1
SCHEMBL2163929	0.89	KDM4E (0.43)	ALDH1A1TSHRPIK3CDKDM4EKMT2A
SCHEMBL2016485	0.88	PIK3CD (0.41)	ALDH1A1PIK3CDKDM4EL3MBTL1MAPT
SCHEMBL2017432	0.88	PIK3CD (0.42)	PIK3CDKMT2AL3MBTL1MAPTRAB9A
SCHEMBL2017857	0.88	PIK3CD (0.42)	ALDH1A1PIK3CDKDM4EL3MBTL1MAPT
SCHEMBL12471366	0.87	PIK3CD (0.39)	ALDH1A1PIK3CDTDP1KMT2AL3MBTL1
SCHEMBL2041868	0.87	PIK3CD (0.40)	ALDH1A1PIK3CDTDP1KDM4EKMT2A
SCHEMBL2163344	0.86	PIK3CD (0.43)	ALDH1A1PIK3CDTDP1KDM4EKMT2A
SCHEMBL2163953	0.86	PIK3CD (0.43)	ALDH1A1TSHRPIK3CDKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8680108-B2	Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors	INCYTE CORPORATION (US)	2014-03-25	—	—	US	claimed
US-20110183985-A1	SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS	INCYTE CORPORATION	2011-07-28	—	—	US	claimed
WO-2011075630-A1	SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS	INCYTE CORPORATION (US)	2011-06-23	—	—	WO	claimed
US-8680108-B2	Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors	INCYTE CORPORATION (US)	2014-03-25	—	—	US	disclosed
US-8680108-B2	Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors	INCYTE CORPORATION (US)	2014-03-25	—	—	US	disclosed
US-20110183985-A1	SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS	INCYTE CORPORATION	2011-07-28	—	—	US	disclosed
US-20110183985-A1	SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS	INCYTE CORPORATION	2011-07-28	—	—	US	disclosed
WO-2011075630-A1	SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS	INCYTE CORPORATION (US)	2011-06-23	—	—	WO	disclosed
WO-2011075630-A1	SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS	INCYTE CORPORATION (US)	2011-06-23	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20110183985-A1	SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS	PIK3R1, PIK3R3, PIK3R2	ALDH1A1 3722/4885TSHR 1701/4885PIK3CD 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.