Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.33 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.33 |
| ▸ | PRKCI | P41743 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1057965 | 0.79 | HRH4 (0.51) | DYRK1AHRH4ADORA2AADORA1IKBKB | |
| Hydrochloric Acid SCHEMBL28275524 | 0.78 | HRH4 (0.50) | DYRK1AHRH4ADORA2AADORA1IKBKB | |
| SCHEMBL1016847 | 0.76 | DYRK1A (0.46) | DYRK1AHRH4ADORA2AADORA1IKBKB | |
| SCHEMBL1689372 | 0.76 | DYRK1A (0.46) | DYRK1AHRH4ADORA2AADORA1IKBKB | |
| SCHEMBL13666508 | 0.76 | PRKCI (0.41) | DYRK1AHRH4ADORA2AADORA1IKBKB | |
| SCHEMBL29981526 | 0.76 | DYRK1A (0.46) | DYRK1AHRH4ADORA2AADORA1IKBKB | |
| SCHEMBL18055932 | 0.76 | DYRK1A (0.46) | DYRK1AHRH4ADORA2AADORA1IKBKB | |
| Hydrochloric Acid SCHEMBL29616498 | 0.74 | DYRK1A (0.44) | DYRK1AHRH4ADORA2AADORA1IKBKB | |
| Hydrochloric Acid SCHEMBL29616579 | 0.74 | DYRK1A (0.44) | DYRK1AHRH4ADORA2AADORA1IKBKB | |
| SCHEMBL12574791 | 0.73 | DYRK1A (0.43) | DYRK1AHRH4ADORA2AADORA1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022260336-A2 | NUCLEOSIDE DERIVATIVE HAVING MULTI-TARGET KINASE INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CANCER COMPRISING SAME | 퓨쳐메디신 주식회사 | 2022-12-15 | — | — | WO | disclosed |
| EP-3541390-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation Therapeutics Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |