Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA5A | P35218 | 2/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL779198 | 0.71 | SRC (0.36) | CA1PARP15PARP10SLC1A3SLC1A2 | |
| SCHEMBL776695 | 0.71 | — | — | |
| SCHEMBL21764940 | 0.70 | SLC1A3 (0.33) | PARP15PARP10PARP2SLC1A3SLC1A2 | |
| SCHEMBL779865 | 0.70 | SRC (0.39) | CA1PARP15PARP10SLC1A3SLC1A2 | |
| SCHEMBL11520489 | 0.66 | — | — | |
| SCHEMBL30427433 | 0.66 | PARP15 (0.42) | PARP15PARP10PARP2SLC1A3SLC1A2 | |
| SCHEMBL111361 | 0.66 | — | — | |
| SCHEMBL12254976 | 0.65 | SRC (0.31) | — | |
| SCHEMBL22662532 | 0.65 | SRC (0.31) | — | |
| SCHEMBL17034252 | 0.65 | TP53 (0.38) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541396-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | Arcus Biosciences, Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018094148-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | ARCUS BIOSCIENCES, INC. (US) | 2018-05-24 | — | — | WO | disclosed |