Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.37 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16699050 | 0.71 | SCN9A (1.00) | SCN9ALMNAMETMCHR1RAB9A | |
| SCHEMBL16699049 | 0.71 | SCN9A (1.00) | SCN9ALMNAMETMCHR1RAB9A | |
| SCHEMBL6440195 | 0.67 | RPS6KB1 (0.49) | LMNARAB9ANPC1MAPTKDM4E | |
| SCHEMBL16699310 | 0.66 | SCN9A (0.76) | SCN9AMETMCHR1GRIA1CACNG8 | |
| SCHEMBL18632085 | 0.65 | DAO (0.38) | ALDH1A1 | |
| SCHEMBL16698862 | 0.65 | SCN9A (0.68) | SCN9AMETMCHR1GRIA1CACNG8 | |
| SCHEMBL16698864 | 0.65 | SCN9A (0.68) | SCN9AMETMCHR1GRIA1CACNG8 | |
| SCHEMBL16698841 | 0.64 | SCN9A (1.00) | SCN9AMETMCHR1GRIA1CACNG8 | |
| SCHEMBL16699280 | 0.64 | SCN9A (0.63) | SCN9ARAB9AGRIA1CACNG8CACNG2 | |
| SCHEMBL19646284 | 0.64 | SCN9A (0.67) | SCN9ALMNAMETMCHR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975858-B2 | Benzimidazole derivatives and use thereof | PURDUE PHARMA L.P. (US) | 2018-05-22 | — | — | US | disclosed |
| US-9975858-B2 | Benzimidazole derivatives and use thereof | PURDUE PHARMA L.P. (US) | 2018-05-22 | — | — | US | disclosed |