Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 15/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13417010 | 0.94 | S1PR1 (1.00) | S1PR1SMN1; SMN2S1PR3MAPTHSD17B10 | |
| SCHEMBL14331460 | 0.89 | S1PR1 (0.89) | S1PR1SMN1; SMN2S1PR3MAPTHSD17B10 | |
| SCHEMBL14327909 | 0.87 | S1PR1 (0.83) | S1PR1SMN1; SMN2S1PR3MAPTHSD17B10 | |
| SCHEMBL13525822 | 0.86 | S1PR1 (0.81) | S1PR1SMN1; SMN2S1PR3MAPTHSD17B10 | |
| SCHEMBL13417013 | 0.85 | S1PR1 (1.00) | S1PR1SMN1; SMN2S1PR3MAPTHSD17B10 | |
| SCHEMBL13416965 | 0.83 | S1PR1 (0.79) | S1PR1SMN1; SMN2S1PR3MAPTHSD17B10 | |
| SCHEMBL13417011 | 0.81 | S1PR1 (1.00) | S1PR1S1PR3 | |
| SCHEMBL13416501 | 0.81 | S1PR1 (1.00) | S1PR1SMN1; SMN2S1PR3MAPTHSD17B10 | |
| SCHEMBL13416964 | 0.80 | S1PR1 (1.00) | S1PR1SMN1; SMN2S1PR3MAPTHSD17B10 | |
| SCHEMBL13417216 | 0.79 | S1PR1 (1.00) | S1PR1SMN1; SMN2S1PR3MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975863-B2 | Modulators of sphingosine phosphate receptors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |