Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 15/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15003293 | 0.85 | MAPK8 (0.39) | MAPK8MAPK9GBA1JAK1TYK2 | |
| SCHEMBL2210310 | 0.84 | MAPK8 (0.44) | MAPK8MAPK9GBA1JAK1TYK2 | |
| SCHEMBL2210308 | 0.84 | MAPK8 (0.44) | MAPK8MAPK9GBA1JAK1TYK2 | |
| SCHEMBL18674150 | 0.82 | MAPK8 (0.39) | MAPK8MAPK9GBA1JAK1TYK2 | |
| SCHEMBL15001243 | 0.82 | MAPK8 (0.39) | MAPK8MAPK9GBA1JAK1TYK2 | |
| SCHEMBL15001193 | 0.82 | MAPK8 (0.39) | MAPK8MAPK9GBA1IRAK4 | |
| SCHEMBL19484934 | 0.81 | MAPK8 (0.43) | MAPK8MAPK9GBA1JAK1TYK2 | |
| SCHEMBL16272822 | 0.81 | MAPK8 (0.43) | MAPK8MAPK9GBA1JAK1TYK2 | |
| SCHEMBL20382767 | 0.80 | MAPK8 (0.40) | MAPK8MAPK9GBA1IRAK4 | |
| SCHEMBL153313 | 0.78 | MAPK8 (0.41) | MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9974786-B2 | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3- B]pyrazin-2(1H)-one, a solid form there of and methods of their use | SIGNAL PHARMACEUTICALS, LLC (US) | 2018-05-22 | — | — | US | disclosed |