Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | TACR2 | P21452 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SHBG | P04278 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | TST | Q16762 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28732505 | 0.93 | ESR1 (0.62) | ACHEESR1ADRA2AADORA3TACR2 | |
| SCHEMBL237709 | 0.93 | ESR1 (0.62) | ACHEESR1ADRA2AADORA3TACR2 | |
| SCHEMBL9616667 | 0.93 | ESR1 (0.62) | ACHEESR1ADRA2AADORA3TACR2 | |
| SCHEMBL6257497 | 0.93 | ESR1 (0.62) | ACHEESR1ADRA2AADORA3TACR2 | |
| SCHEMBL9616718 | 0.93 | ESR1 (0.62) | ACHEESR1ADRA2AADORA3TACR2 | |
| SCHEMBL573990 | 0.93 | ESR1 (0.62) | ACHEESR1ADRA2AADORA3TACR2 | |
| SCHEMBL27562507 | 0.91 | ESR1 (0.60) | ACHEESR1ADRA2AADORA3TACR2 | |
| SCHEMBL27814051 | 0.91 | ESR1 (0.60) | ACHEESR1ADRA2AADORA3TACR2 | |
| SCHEMBL980192 | 0.91 | SLC6A2 (0.59) | ACHEESR1ADRA2AADORA3TACR2 | |
| Phenol SCHEMBL9721875 | 0.89 | TRPV1 (0.53) | ACHEESR1ADRA2AADORA3TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738025-B2 | Method for extruding plastic masses | COVESTRO DEUTSCHLAND AG (DE) | 2017-08-22 | — | — | US | disclosed |
| US-20110160381-A1 | METHOD FOR EXTRUDING PLASTIC MASSES | COVESTRO DEUTSCHLAND AG (DE) | 2011-06-30 | — | — | US | disclosed |