Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 6/20 | 0.52 |
| ▸ | PDE9A | O76083 | 11/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12498824 | 0.87 | EZH2 (0.57) | EZH2PDE9APDE1B | |
| SCHEMBL12498746 | 0.86 | EZH2 (0.56) | EZH2PDE9AGRM1 | |
| SCHEMBL12499903 | 0.84 | EZH2 (0.55) | EZH2PDE9APDE1C | |
| SCHEMBL12499545 | 0.78 | EZH2 (0.59) | EZH2PDE1CPDE1BPDE1A | |
| SCHEMBL19391456 | 0.76 | EZH2 (0.44) | EZH2PDE9APDE1CPDE1BPDE1A | |
| SCHEMBL12499146 | 0.75 | EZH2 (0.47) | EZH2PDE1CPDE1B | |
| SCHEMBL14894949 | 0.74 | EZH2 (0.45) | EZH2 | |
| SCHEMBL12499304 | 0.69 | EZH2 (1.00) | EZH2 | |
| SCHEMBL12499097 | 0.69 | EZH2 (0.98) | EZH2 | |
| SCHEMBL26695316 | 0.68 | EZH2 (0.46) | EZH2PDE9APDE1CGRM1PDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |