Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11901790 | 0.88 | MKNK1 (0.43) | MKNK1MKNK2EGFRERBB2FYN | |
| SCHEMBL6836639 | 0.79 | MEN1 (0.55) | HDAC1HDAC3NCOR1MAPK14CDK5 | |
| SCHEMBL27956437 | 0.78 | EGFR (0.47) | MKNK1MKNK2EGFRERBB2FYN | |
| SCHEMBL7677416 | 0.77 | MAPK10 (0.56) | MKNK1EGFRHDAC1HDAC3 | |
| SCHEMBL16657381 | 0.77 | RAD52 (0.50) | HDAC1HDAC3NCOR1MAPK14 | |
| SCHEMBL16657370 | 0.77 | MKNK1 (0.44) | MKNK1MKNK2EGFREIF4EGSK3A | |
| SCHEMBL18387056 | 0.76 | AURKA (0.44) | HDAC1HDAC3NCOR1MAPK14 | |
| SCHEMBL11901159 | 0.74 | HTT (0.47) | MKNK1MKNK2MPL | |
| SCHEMBL16996884 | 0.73 | GSK3A (0.48) | MKNK1MKNK2EGFRERBB2FYN | |
| SCHEMBL30611577 | 0.73 | MEN1 (0.56) | MKNK1MKNK2EGFRERBB2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323817-A1 | ANILINE PYRIMIDINE DERIVATIVES AND USES THEREOF | Chia Tai Tianqing Pharmaceutical Group Co.,Ltd (CN) | 2018-05-23 | — | — | EP | disclosed |