Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23435921 | 1.00 | DPP4 (0.40) | DPP4HRH3CYP1A2MAPT | |
| SCHEMBL25585003 | 0.89 | CA1 (0.31) | DPP4 | |
| SCHEMBL19014993 | 0.84 | DPP4 (0.36) | DPP4 | |
| SCHEMBL25045297 | 0.84 | DPP4 (0.36) | DPP4 | |
| SCHEMBL14593674 | 0.82 | — | — | |
| SCHEMBL21145551 | 0.82 | — | — | |
| SCHEMBL26170436 | 0.82 | — | — | |
| SCHEMBL14038216 | 0.82 | — | — | |
| SCHEMBL26170333 | 0.82 | — | — | |
| SCHEMBL18968491 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068391-B1 | ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME (US) | 2018-05-23 | — | — | EP | disclosed |