Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 14/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.81 |
| ▸ | POLB | P06746 | 12/20 | 0.81 |
| ▸ | PKM | P14618 | 11/20 | 0.81 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.81 |
| ▸ | LMNA | P02545 | 10/20 | 0.81 |
| ▸ | TSHR | P16473 | 8/20 | 0.81 |
| ▸ | GAA | P10253 | 1/20 | 0.81 |
| ▸ | RAB9A | P51151 | 1/20 | 0.81 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.81 |
| ▸ | ESR1 | P03372 | 5/20 | 0.81 |
| ▸ | RECQL | P46063 | 4/20 | 0.81 |
| ▸ | APEX1 | P27695 | 3/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.81 |
| ▸ | BLM | P54132 | 2/20 | 0.81 |
| ▸ | HTT | P42858 | 4/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016219 | 0.94 | SMN1; SMN2 (0.87) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 | |
| SCHEMBL2017482 | 0.94 | POLB (0.85) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 | |
| SCHEMBL2015769 | 0.90 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 | |
| SCHEMBL2015501 | 0.90 | POLB (1.00) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 | |
| SCHEMBL2014912 | 0.89 | POLB (1.00) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 | |
| SCHEMBL2014615 | 0.89 | SMN1; SMN2 (0.98) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 | |
| SCHEMBL2016888 | 0.89 | POLB (0.84) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 | |
| SCHEMBL2018215 | 0.87 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 | |
| SCHEMBL2016403 | 0.87 | POLB (0.81) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 | |
| SCHEMBL2021255 | 0.86 | POLB (0.83) | SMN1; SMN2ALDH1A1POLBPKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073929-A1 | 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073929-A1 | 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073929-A1 | 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2011-06-23 | — | — | WO | disclosed |