Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 18/20 | 0.83 |
| ▸ | GAK | O14976 | 2/20 | 0.83 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.83 |
| ▸ | RIPK3 | Q9Y572 | 6/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14697655 | 0.91 | RIPK2 (1.00) | RIPK2GAKNOD2RIPK3 | |
| SCHEMBL29508237 | 0.91 | RIPK2 (1.00) | RIPK2GAKNOD2RIPK3 | |
| SCHEMBL14706943 | 0.91 | RIPK2 (0.84) | RIPK2GAKNOD2RIPK3 | |
| SCHEMBL14706920 | 0.91 | RIPK2 (0.87) | RIPK2GAKNOD2RIPK3RIPK1 | |
| SCHEMBL14698021 | 0.90 | RIPK2 (0.82) | RIPK2GAKNOD2RIPK3RIPK1 | |
| SCHEMBL14706917 | 0.90 | RIPK2 (0.92) | RIPK2GAKNOD2RIPK3RIPK1 | |
| SCHEMBL14697945 | 0.89 | RIPK2 (0.84) | RIPK2GAKNOD2RIPK3RIPK1 | |
| SCHEMBL25771943 | 0.89 | RIPK2 (0.84) | RIPK2GAKNOD2RIPK3RIPK1 | |
| SCHEMBL14706913 | 0.89 | RIPK2 (0.84) | RIPK2GAKNOD2RIPK3 | |
| SCHEMBL31500671 | 0.89 | RIPK2 (1.00) | RIPK2GAKNOD2RIPK3RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323819-B1 | COMBINATIONS OF RIP2 KINASE INHIBITOR PRODRUG 2-((4-(BENZO[D]THIAZOL-5-YLAMINO)-6-(TERT. -BUTYLSULFONYL)QUINAZOLIN-7-YL)OXY)ETHYL DIHYDROGEN PHOSPHATE WITH OTHER THERAPEUTIC AGENTS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-02-26 | — | — | EP | disclosed |
| EP-3323819-A1 | PRODRUGS OF AMINO QUINAZOLINE KINASE INHIBITOR | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-05-23 | — | — | EP | disclosed |