Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 14/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | SCNN1B | P51168 | 1/20 | 0.44 |
| ▸ | SCNN1G | P51170 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.34 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12636698 | 0.99 | SCNN1A (0.45) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL2020727 | 0.92 | SCNN1A (0.46) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2020004 | 0.91 | SCNN1A (0.44) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2043292 | 0.91 | SCNN1A (0.44) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2015067 | 0.90 | SCNN1A (0.43) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12635781 | 0.90 | SCNN1A (0.44) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12636291 | 0.90 | SCNN1A (0.45) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12635780 | 0.89 | SCNN1A (0.44) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2016135 | 0.89 | SCNN1A (0.43) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2018332 | 0.89 | KCNH2 (0.47) | SCNN1ADRD5SCNN1BSCNN1GHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | claimed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |