Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 1.00 |
| ▸ | EGFR | P00533 | 8/20 | 1.00 |
| ▸ | LCK | P06239 | 6/20 | 1.00 |
| ▸ | ITK | Q08881 | 5/20 | 1.00 |
| ▸ | LYN | P07948 | 4/20 | 1.00 |
| ▸ | TEC | P42680 | 4/20 | 1.00 |
| ▸ | BMX | P51813 | 4/20 | 1.00 |
| ▸ | ABL1 | P00519 | 2/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 2/20 | 1.00 |
| ▸ | FYN | P06241 | 2/20 | 1.00 |
| ▸ | YES1 | P07947 | 2/20 | 1.00 |
| ▸ | HCK | P08631 | 2/20 | 1.00 |
| ▸ | FGR | P09769 | 2/20 | 1.00 |
| ▸ | SRC | P12931 | 2/20 | 1.00 |
| ▸ | FER | P16591 | 2/20 | 1.00 |
| ▸ | CSK | P41240 | 2/20 | 1.00 |
| ▸ | BLK | P51451 | 2/20 | 1.00 |
| ▸ | JAK3 | P52333 | 2/20 | 1.00 |
| ▸ | PTK6 | Q13882 | 2/20 | 1.00 |
| ▸ | ERBB4 | Q15303 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460731 | 1.00 | BTK (1.00) | BTKEGFRLCKITKLYN | |
| SCHEMBL793463 | 1.00 | BTK (1.00) | BTKEGFRLCKITKLYN | |
| SCHEMBL201744 | 1.00 | BTK (1.00) | BTKEGFRLCKITKLYN | |
| SCHEMBL18645941 | 0.92 | BTK (0.86) | BTKEGFRLCKITKLYN | |
| SCHEMBL21884773 | 0.91 | BTK (0.84) | BTKEGFRLCKITKLYN | |
| SCHEMBL410200 | 0.90 | BTK (0.82) | BTKEGFRLCKITKLYN | |
| SCHEMBL15163865 | 0.90 | BTK (0.82) | BTKEGFRLCKITKLYN | |
| SCHEMBL17065693 | 0.90 | BTK (0.82) | BTKEGFRLCKITKLYN | |
| SCHEMBL13545383 | 0.88 | BTK (0.78) | BTKEGFRLCKITKLYN | |
| SCHEMBL19590176 | 0.88 | BTK (0.77) | BTKEGFRLCKITKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 335 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170007611-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. | 2017-01-12 | — | — | US | claimed |
| US-20150152115-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC | 2015-06-04 | — | — | US | claimed |
| US-8952015-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS, INC. (US) | 2015-02-10 | — | — | US | claimed |
| US-20140171453-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2014-06-19 | — | — | US | claimed |
| US-20140135347-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2014-05-15 | — | — | US | claimed |
| US-20130018060-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2013-01-17 | — | — | US | claimed |
| EP-2529622-A1 | Inhibitors of bruton's tyrosine kinase | Pharmacyclics, Inc. (US) | 2012-12-05 | — | — | EP | claimed |
| US-20120277254-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2012-11-01 | — | — | US | claimed |
| US-20120277225-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2012-11-01 | — | — | US | claimed |
| US-20120277255-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2012-11-01 | — | — | US | claimed |
| EP-2201840-B1 | Inhibitors of Bruton's Tyrosine Kinase | PHARMACYCLICS INC (US) | 2011-11-02 | — | — | EP | claimed |
| US-8008309-B2 | Inhibitors of bruton's tyrosine kinase | PHARMACYCLICS, INC. (US) | 2011-08-30 | — | — | US | claimed |
| US-20110039868-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2011-02-17 | — | — | US | claimed |
| US-20110008257-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2011-01-13 | — | — | US | claimed |
| EP-2201840-A1 | Inhibitors of Bruton's Tyrosine Kinase | Pharmacyclics, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| US-20100041677-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2010-02-18 | — | — | US | claimed |
| US-20100022561-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2010-01-28 | — | — | US | claimed |
| US-7514444-B2 | Inhibitors of bruton's tyrosine kinase | PHARMACYCLICS, INC. (US) | 2009-04-07 | — | — | US | claimed |
| US-20080139582-A1 | 4-Amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives; can be covalently bonded to Bruton's tyrosine kinase; autoimmune diseases, lymphoma, leukemia; antiproliferative, anticarcinogenic and antiinflammatory agents | PHARMACYCLICS, INC. (US) | 2008-06-12 | — | — | US | claimed |
| US-20080076921-A1 | 4-Amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives; can be covalently bonded to Bruton's tyrosine kinase; autoimmune diseases, lymphoma, leukemia; antiproliferative, anticarcingogenic and antiinflammatory agents | PHARMACYCLICS, INC. (US) | 2008-03-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277255-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885LCK 23/4885 |
| US-20100022561-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LCK, LYN | BTK 1/4885EGFR 836/4885LCK 2/4885 |
| US-20140171453-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LCK, LYN | BTK 1/4885EGFR 836/4885LCK 2/4885 |
| US-20170007611-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LCK, LYN | BTK 1/4885EGFR 836/4885LCK 2/4885 |
| US-20120277254-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LCK, LYN | BTK 1/4885EGFR 836/4885LCK 2/4885 |
| US-20100041677-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LCK, LYN | BTK 1/4885EGFR 836/4885LCK 2/4885 |
| US-20110039868-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LCK, LYN | BTK 1/4885EGFR 836/4885LCK 2/4885 |
| US-20120277225-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885LCK 23/4885 |
| US-20150152115-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885LCK 23/4885 |
| US-20130018060-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885EGFR 697/4885LCK 23/4885 |
| US-20110008257-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LCK, LYN | BTK 1/4885EGFR 836/4885LCK 2/4885 |
| US-20140135347-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LCK, LYN | BTK 1/4885EGFR 836/4885LCK 2/4885 |
| US-20080139582-A1 | 4-Amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives; can be covalently bonded to Bruton's tyrosine kinase; autoimmune diseases, lymphoma, leukemia; antiproliferative, anticarcinogenic and antiinflammatory agents | BTK, LCK, LYN | BTK 1/4885EGFR 1536/4885LCK 2/4885 |
| US-20080076921-A1 | 4-Amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives; can be covalently bonded to Bruton's tyrosine kinase; autoimmune diseases, lymphoma, leukemia; antiproliferative, anticarcingogenic and antiinflammatory agents | BTK, LCK, LYN | BTK 1/4885EGFR 1550/4885LCK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.