Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 19/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.68 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16836077 | 0.87 | KCNJ1 (0.62) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL24135126 | 0.86 | KCNJ1 (0.59) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL18019265 | 0.86 | KCNJ1 (0.69) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL19264534 | 0.84 | KCNJ1 (0.68) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL19433455 | 0.83 | KCNJ1 (0.66) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL22718938 | 0.81 | KCNJ1 (0.62) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL22718883 | 0.81 | KCNJ1 (0.62) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL20176945 | 0.81 | KCNJ1 (0.46) | KCNJ1KCNH2 | |
| SCHEMBL10234057 | 0.81 | KCNJ1 (1.00) | KCNJ1KCNH2 | |
| SCHEMBL296398 | 0.78 | KCNJ1 (0.60) | KCNJ1KCNH2ACHESSTR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535258-B1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-11-24 | — | — | EP | disclosed |
| WO-2018093569-A1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-24 | — | — | WO | disclosed |