Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.58 |
| ▸ | BCL2 | P10415 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | MERTK | Q12866 | 2/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2164726 | 1.00 | PIK3CD (0.58) | PIK3CDBCL2AXLMERTKSOS1 | |
| SCHEMBL2165865 | 0.81 | PIK3CD (0.47) | PIK3CDBCL2SOS1 | |
| Adipic Acid SCHEMBL2163627 | 0.80 | PIK3CD (0.68) | PIK3CDBCL2AXLMERTKPIK3CG | |
| Adipic Acid SCHEMBL2017684 | 0.80 | PIK3CD (0.68) | PIK3CDBCL2AXLMERTKPIK3CG | |
| SCHEMBL31405546 | 0.77 | PIK3CD (0.79) | PIK3CDBCL2AXLMERTKPIK3CG | |
| SCHEMBL2014247 | 0.77 | PIK3CD (0.79) | PIK3CDBCL2AXLMERTKPIK3CG | |
| SCHEMBL2163350 | 0.77 | PIK3CD (0.79) | PIK3CDBCL2AXLMERTKPIK3CG | |
| SCHEMBL30194068 | 0.77 | PIK3CD (0.79) | PIK3CDBCL2AXLMERTKPIK3CG | |
| SCHEMBL2038100 | 0.77 | PIK3CD (0.41) | PIK3CDBCL2RPS6KB1 | |
| SCHEMBL2164179 | 0.76 | PIK3CD (0.41) | PIK3CDBCL2SOS1PDPK1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |