Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 20/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21265975 | 1.00 | KCNJ1 (0.39) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL20168135 | 0.89 | KCNJ1 (0.43) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL20168133 | 0.89 | KCNJ1 (0.43) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL21266199 | 0.88 | KCNJ1 (0.45) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL20176984 | 0.88 | KCNJ1 (0.45) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL21265973 | 0.86 | KCNJ1 (0.40) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL21265947 | 0.83 | KCNJ1 (0.48) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL20177025 | 0.83 | KCNJ1 (0.48) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL21265960 | 0.83 | KCNJ1 (0.49) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL21265972 | 0.83 | KCNJ1 (0.46) | KCNJ1KCNH2ACHESSTR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139862-B | Substituted bicyclic heterocyclic derivatives useful as ROMK channel inhibitors | 百时美施贵宝公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2018093569-A1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-24 | — | — | WO | disclosed |