Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20177562 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EGAAKMT2AHPGD | |
| SCHEMBL20166584 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EKMT2AHPGDMEN1 | |
| SCHEMBL20177576 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EGAAKMT2AHPGD | |
| SCHEMBL20166559 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EGAAKMT2AHPGD | |
| SCHEMBL20166557 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EGAAKMT2AHPGD | |
| SCHEMBL19573914 | 0.72 | ITGB1 (0.40) | SMN1; SMN2KDM4EGAAKMT2AHPGD | |
| SCHEMBL19573915 | 0.72 | ITGB1 (0.40) | SMN1; SMN2KDM4EGAAKMT2AHPGD | |
| SCHEMBL9191011 | 0.71 | MAPK1 (0.47) | SMN1; SMN2KDM4EKMT2AHPGDMEN1 | |
| SCHEMBL11422545 | 0.69 | ATM (0.47) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL20166840 | 0.69 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EKMT2AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093577-A1 | CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |