Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.30 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1961937 | 0.79 | GCK (0.49) | PIK3C3LOX | |
| SCHEMBL1961927 | 0.77 | LOX (0.33) | PIK3C3LOX | |
| SCHEMBL1962660 | 0.77 | GCK (0.42) | — | |
| SCHEMBL1960330 | 0.72 | GCK (0.46) | PIK3C3LOX | |
| SCHEMBL1960332 | 0.72 | GCK (0.46) | PIK3C3LOX | |
| SCHEMBL10819875 | 0.70 | CDK1 (0.35) | — | |
| SCHEMBL10819876 | 0.70 | CDK1 (0.35) | — | |
| SCHEMBL1959111 | 0.70 | GCK (0.40) | LOX | |
| SCHEMBL1959614 | 0.66 | GCK (0.50) | — | |
| SCHEMBL1959970 | 0.64 | GCK (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |