Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17151142 | 0.84 | PIK3CA (0.47) | PIK3CAMTORPDE10ACCNCCDK8 | |
| SCHEMBL12445267 | 0.83 | PIK3CA (0.46) | PIK3CAMTORPDE10ALRRK2MIF | |
| SCHEMBL30884507 | 0.81 | PIK3CA (0.47) | PIK3CAMTORPDE10ACCNCCDK8 | |
| SCHEMBL15651208 | 0.81 | PIK3CA (0.47) | PIK3CAMTORPDE10ACCNCCDK8 | |
| SCHEMBL20180814 | 0.81 | F10 (0.47) | MTORLRRK2 | |
| SCHEMBL21376420 | 0.81 | PIK3CA (0.44) | PIK3CAMTORPDE10ACCNCCDK8 | |
| SCHEMBL17148220 | 0.81 | PIK3CA (0.44) | PIK3CAMTORPDE10ACCNCCDK8 | |
| SCHEMBL30602385 | 0.80 | PIK3CA (0.46) | PIK3CAMTORPDE10ACCNCCDK8 | |
| SCHEMBL9997046 | 0.80 | PIK3CA (0.46) | PIK3CAMTORPDE10ACCNCCDK8 | |
| SCHEMBL14146011 | 0.80 | PIK3CA (0.46) | PIK3CAMTORPDE10ACCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093579-A1 | TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |