Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.57 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | COMT | P21964 | 2/20 | 0.57 |
| ▸ | MMP2 | P08253 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | METAP1 | P53582 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19001628 | 0.80 | KDM4E (0.48) | KDM4EL3MBTL1NPC1RAB9ACOMT | |
| SCHEMBL11808148 | 0.80 | COMT (0.61) | KDM4EL3MBTL1NPC1RAB9ACOMT | |
| SCHEMBL20176005 | 0.78 | KDM4E (0.59) | KDM4EL3MBTL1NPC1RAB9ACOMT | |
| SCHEMBL3711196 | 0.78 | KDM4E (0.59) | KDM4EL3MBTL1NPC1RAB9ACOMT | |
| SCHEMBL364531 | 0.77 | KDM4E (0.57) | KDM4EL3MBTL1NPC1RAB9ACOMT | |
| SCHEMBL3347624 | 0.77 | KDM4E (0.57) | KDM4EL3MBTL1NPC1RAB9ACOMT | |
| SCHEMBL22271011 | 0.77 | CCR1 (0.45) | KDM4EL3MBTL1NPC1RAB9ACOMT | |
| SCHEMBL22270741 | 0.77 | CCR1 (0.55) | KDM4EL3MBTL1COMTMMP2TSHR | |
| SCHEMBL20176000 | 0.77 | KDM4E (0.57) | KDM4EL3MBTL1NPC1RAB9ACOMT | |
| SCHEMBL19001540 | 0.77 | CCR1 (0.55) | KDM4EL3MBTL1NPC1RAB9ACOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141911-A1 | Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease | NORTHEASTERN UNIVERSITY | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141911-A1 | Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease | MAPT, PSEN1, PSEN2 | KDM4E 3865/4885L3MBTL1 2472/4885NPC1 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.