Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.35 |
| ▸ | KDR | P35968 | 8/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 6/20 | 0.33 |
| ▸ | LCK | P06239 | 4/20 | 0.33 |
| ▸ | TEK | Q02763 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182216 | 0.83 | KDR (0.40) | RETKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20162795 | 0.82 | KDR (0.42) | RETKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20173304 | 0.82 | KDR (0.40) | RETKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30036859 | 0.82 | KDR (0.42) | RETKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20175297 | 0.78 | KDR (0.42) | RETKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20175447 | 0.78 | KDR (0.40) | RETKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20175829 | 0.78 | KDR (0.43) | RETKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30892139 | 0.78 | KDR (0.40) | RETKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20173308 | 0.77 | KDR (0.42) | RETKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20162933 | 0.77 | PIK3CD (0.43) | RETKDRPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |