Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 10/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 2/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182238 | 0.90 | CFTR (0.36) | CFTRNOTUMGRM1GRM5RXRA | |
| SCHEMBL20162879 | 0.81 | CFTR (0.49) | CFTRNOTUM | |
| SCHEMBL20162875 | 0.76 | CFTR (0.45) | CFTRNOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL30037449 | 0.76 | CFTR (0.45) | CFTRNOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL20162877 | 0.75 | CFTR (0.46) | CFTRNOTUM | |
| SCHEMBL30892146 | 0.75 | CFTR (0.46) | CFTRNOTUM | |
| SCHEMBL20162728 | 0.72 | CFTR (0.59) | CFTRNOTUM | |
| SCHEMBL30036823 | 0.72 | CFTR (0.59) | CFTRNOTUM | |
| SCHEMBL30037958 | 0.72 | CFTR (0.56) | CFTR | |
| SCHEMBL20162615 | 0.72 | CFTR (0.56) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |