Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 14/20 | 0.81 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20115776 | 0.91 | SCN5A (0.81) | SCN5ASCN9ACYP3A4 | |
| SCHEMBL30479350 | 0.90 | SCN5A (1.00) | SCN5ASCN9ACYP3A4 | |
| SCHEMBL20115735 | 0.90 | SCN5A (1.00) | SCN5ASCN9ACYP3A4 | |
| SCHEMBL20115621 | 0.89 | SCN5A (1.00) | SCN5ASCN9ACYP3A4 | |
| SCHEMBL30479363 | 0.89 | SCN5A (1.00) | SCN5ASCN9ACYP3A4 | |
| SCHEMBL21680255 | 0.89 | SCN5A (1.00) | SCN5ASCN9ACYP3A4 | |
| SCHEMBL20115552 | 0.89 | SCN5A (1.00) | SCN5ASCN9ACYP3A4 | |
| SCHEMBL30479365 | 0.89 | SCN5A (1.00) | SCN5ASCN9ACYP3A4 | |
| SCHEMBL20115591 | 0.86 | SCN5A (0.74) | SCN5ASCN9ACYP3A4 | |
| SCHEMBL20115722 | 0.85 | SCN5A (0.71) | SCN5ASCN9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541373-B1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME LLC (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2018093694-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |