Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20522096 | 0.83 | HSD17B10 (0.49) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL1401178 | 0.83 | HSD17B10 (0.49) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL18497645 | 0.81 | ATM (0.44) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL18497643 | 0.81 | ATM (0.44) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL12997526 | 0.80 | HSD17B10 (0.48) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL20805862 | 0.80 | HSD17B10 (0.48) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL337037 | 0.80 | HSD17B10 (0.48) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL16978942 | 0.80 | HSD17B10 (0.48) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL337349 | 0.80 | HSD17B10 (0.48) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL205359 | 0.80 | HSD17B10 (0.48) | HSD17B10PDE8BSMN1; SMN2ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093694-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |