Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.67 |
| ▸ | SCN5A | Q14524 | 13/20 | 0.66 |
| ▸ | SCN1A | P35498 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25974863 | 0.92 | SCN9A (0.67) | SCN9ACYP3A4SCN5ASCN1A | |
| SCHEMBL18983164 | 0.91 | SCN5A (0.69) | SCN9ACYP3A4SCN5ASCN1A | |
| SCHEMBL18992442 | 0.89 | SCN9A (0.70) | SCN9ACYP3A4SCN5ASCN1A | |
| SCHEMBL18992504 | 0.88 | SCN9A (0.67) | SCN9ACYP3A4SCN5ASCN1A | |
| SCHEMBL19008514 | 0.88 | SCN9A (0.69) | SCN9ACYP3A4SCN5ASCN1A | |
| SCHEMBL19001199 | 0.88 | SCN5A (0.61) | SCN9ACYP3A4SCN5ASCN1A | |
| SCHEMBL19401003 | 0.88 | SCN9A (0.69) | SCN9ACYP3A4SCN5A | |
| SCHEMBL18992285 | 0.87 | SCN9A (0.66) | SCN9ACYP3A4SCN5ASCN1A | |
| SCHEMBL19000816 | 0.87 | SCN5A (0.62) | SCN9ACYP3A4SCN5ASCN1A | |
| SCHEMBL20586160 | 0.87 | SCN5A (0.64) | SCN9ACYP3A4SCN5ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093694-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |