Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072406 | 0.85 | KDM4E (0.36) | KDM4EYTHDC1STAT3HIF1ASMN1; SMN2 | |
| SCHEMBL2016070 | 0.75 | KDM4E (0.41) | KDM4EYTHDC1STAT3HIF1ASMN1; SMN2 | |
| SCHEMBL135237 | 0.74 | CYP1A2 (0.39) | CYP1A2 | |
| SCHEMBL217086 | 0.73 | KDM4E (0.67) | KDM4EYTHDC1STAT3HIF1ASMN1; SMN2 | |
| SCHEMBL29781840 | 0.73 | KDM4E (0.67) | KDM4EYTHDC1STAT3HIF1ASMN1; SMN2 | |
| SCHEMBL2564745 | 0.72 | PDPK1 (0.47) | KDM4EKMT2APOLBFLT3ALDH1A1 | |
| SCHEMBL30319401 | 0.71 | KDM4E (0.63) | KDM4ESMN1; SMN2KMT2APOLBCYP1A2 | |
| SCHEMBL16095474 | 0.71 | — | — | |
| SCHEMBL13995824 | 0.71 | KDM4E (0.63) | KDM4ESMN1; SMN2KMT2APOLBCYP1A2 | |
| SCHEMBL2013950 | 0.69 | KDM4E (0.41) | KDM4EYTHDC1STAT3HIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516438-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | Plexxikon, Inc. (US) | 2012-10-31 | — | — | EP | claimed |
| WO-2011079133-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2011-06-30 | — | — | WO | claimed |