Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AIMP2 | Q13155 | 1/20 | 0.47 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.41 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182778 | 0.83 | AIMP2 (0.49) | AIMP2GRM7SIGMAR1KMT2AMEN1 | |
| SCHEMBL20183017 | 0.83 | AIMP2 (0.49) | AIMP2GRM7NPC1L1SIGMAR1PSMB5 | |
| SCHEMBL25626240 | 0.82 | AIMP2 (0.47) | AIMP2GRM7SIGMAR1KMT2AMEN1 | |
| SCHEMBL20182869 | 0.81 | AIMP2 (0.56) | AIMP2GRM7SIGMAR1MAPTPSMB5 | |
| SCHEMBL21542323 | 0.81 | GRM7 (0.64) | GRM7KMT2AMEN1TSHR | |
| SCHEMBL21542325 | 0.81 | GRM7 (0.64) | GRM7KMT2AMEN1TSHR | |
| SCHEMBL20182996 | 0.81 | GRM7 (0.64) | GRM7KMT2AMEN1TSHR | |
| SCHEMBL20182999 | 0.79 | AIMP2 (0.45) | AIMP2GRM7SIGMAR1PSMB5TSHR | |
| SCHEMBL20182785 | 0.78 | AIMP2 (0.52) | AIMP2GRM7SIGMAR1PSMB5POLB | |
| SCHEMBL20182838 | 0.77 | AIMP2 (0.51) | AIMP2GRM7SIGMAR1PSMB5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541812-B1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICALS CO (JP) | 2023-06-14 | — | — | EP | disclosed |
| WO-2018092921-A1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-24 | — | — | WO | disclosed |