Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.47 |
| ▸ | GSPT1 | P15170 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | WIZ | O95785 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19523152 | 0.88 | CRBN (0.53) | CRBNDDB1GSPT1KCNH2CYP2C19 | |
| SCHEMBL21863935 | 0.86 | CRBN (0.46) | CRBNDDB1GSPT1KCNH2CYP2C19 | |
| SCHEMBL20427470 | 0.86 | CRBN (0.55) | CRBNDDB1GSPT1KCNH2CYP2C19 | |
| SCHEMBL21863860 | 0.86 | PTPRZ1 (0.52) | CRBNDDB1GSPT1KCNH2CYP2C19 | |
| SCHEMBL4452280 | 0.85 | CRBN (0.66) | CRBNDDB1GSPT1KCNH2CYP2C19 | |
| SCHEMBL29421149 | 0.85 | CRBN (0.66) | CRBNDDB1GSPT1KCNH2CYP2C19 | |
| SCHEMBL22594133 | 0.82 | CRBN (0.58) | CRBNDDB1GSPT1KCNH2CYP2C19 | |
| SCHEMBL21863911 | 0.81 | TNF (0.46) | CRBNDDB1GSPT1KCNH2CYP2C19 | |
| SCHEMBL24691764 | 0.81 | CRBN (0.52) | CRBNDDB1GSPT1KCNH2CYP2C19 | |
| SCHEMBL22600230 | 0.80 | CRBN (0.64) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327013-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | Celgene Corporation (US) | 2018-05-30 | — | — | EP | disclosed |