Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.78 |
| ▸ | JAK2 | O60674 | 5/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16245380 | 0.88 | JAK3 (1.00) | JAK3JAK2JAK1 | |
| SCHEMBL15032750 | 0.88 | JAK3 (1.00) | JAK3JAK2JAK1 | |
| SCHEMBL20184334 | 0.84 | JAK3 (0.64) | JAK3JAK2AURKA | |
| SCHEMBL20184558 | 0.84 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL20184572 | 0.84 | JAK3 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL20184573 | 0.82 | JAK3 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL20184714 | 0.82 | JAK3 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL15010428 | 0.82 | JAK3 (0.60) | JAK3JAK2JAK1 | |
| SCHEMBL15010433 | 0.82 | JAK3 (0.60) | JAK3JAK2JAK1 | |
| SCHEMBL20184485 | 0.82 | JAK3 (0.77) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |