Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.80 |
| ▸ | JAK2 | O60674 | 4/20 | 0.62 |
| ▸ | BTK | Q06187 | 2/20 | 0.57 |
| ▸ | ITK | Q08881 | 2/20 | 0.57 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.53 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184439 | 0.90 | JAK3 (0.68) | JAK3JAK2JAK1 | |
| SCHEMBL16245069 | 0.89 | JAK3 (1.00) | JAK3JAK2JAK1 | |
| SCHEMBL15032841 | 0.89 | JAK3 (1.00) | JAK3JAK2JAK1 | |
| SCHEMBL20184587 | 0.87 | JAK3 (0.81) | JAK3JAK2JAK1 | |
| SCHEMBL20184714 | 0.87 | JAK3 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL20184573 | 0.87 | JAK3 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL20184364 | 0.86 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL16245266 | 0.85 | JAK3 (0.62) | JAK3JAK2BTKITKPLCG1 | |
| SCHEMBL16245267 | 0.85 | JAK3 (0.62) | JAK3JAK2BTKITKPLCG1 | |
| SCHEMBL20184368 | 0.85 | JAK3 (0.80) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |