Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.79 |
| ▸ | JAK2 | O60674 | 10/20 | 0.79 |
| ▸ | DHODH | Q02127 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MDH2 | P40926 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032782 | 0.88 | JAK3 (1.00) | JAK3JAK2JAK1 | |
| SCHEMBL20184691 | 0.84 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL20184456 | 0.83 | JAK2 (0.61) | JAK3JAK2DHODHNR1H4ALDH1A1 | |
| SCHEMBL20184496 | 0.83 | JAK3 (0.56) | JAK3JAK2JAK1 | |
| SCHEMBL15032652 | 0.82 | JAK3 (0.63) | JAK3JAK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL20184692 | 0.82 | JAK3 (0.70) | JAK3JAK2JAK1 | |
| SCHEMBL20184347 | 0.82 | JAK3 (0.62) | JAK3JAK2JAK1 | |
| SCHEMBL20184432 | 0.81 | JAK3 (0.68) | JAK3JAK2 | |
| SCHEMBL20184531 | 0.79 | JAK3 (0.56) | JAK3JAK2JAK1 | |
| SCHEMBL20184454 | 0.79 | JAK3 (0.70) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |