Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 7/20 | 0.40 |
| ▸ | CSF1R | P07333 | 6/20 | 0.39 |
| ▸ | RAF1 | P04049 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.39 |
| ▸ | ARAF | P10398 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204383 | 0.90 | CSF1R (0.40) | CSF1RRAF1BRAFDDR1DDR2 | |
| SCHEMBL20186959 | 0.83 | FGFR4 (0.44) | FGFR4CSF1RRAF1BRAFDDR1 | |
| SCHEMBL20186913 | 0.83 | SRC (0.45) | FGFR4CSF1RRAF1BRAFDDR1 | |
| SCHEMBL20186911 | 0.82 | FGFR4 (0.42) | FGFR4CSF1RRAF1BRAFDDR1 | |
| SCHEMBL20186946 | 0.82 | MAPK3 (0.44) | FGFR4CSF1RRAF1BRAFDDR1 | |
| SCHEMBL20186909 | 0.82 | FGFR4 (0.41) | FGFR4CSF1RRAF1BRAFDDR1 | |
| SCHEMBL20186929 | 0.81 | FGFR4 (0.54) | FGFR4RAF1BRAFFGFR1 | |
| SCHEMBL20186910 | 0.75 | BMX (0.49) | FGFR4DDR1FGFR1EGFR | |
| SCHEMBL20186950 | 0.74 | BMX (0.61) | CSF1RRAF1BRAFDDR1DDR2 | |
| SCHEMBL20186916 | 0.74 | MAP3K7 (0.49) | FGFR4SRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040803-B2 | 4-((2-acrylamidophenyl)amino)thieno[3,2-D]pyrimidine-7-carboxamide derivatives as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-08-07 | — | — | US | claimed |
| US-20180148459-A1 | 4-((2-ACRYLAMIDOPHENYL)AMINO)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-05-31 | — | — | US | claimed |
| US-10040803-B2 | 4-((2-acrylamidophenyl)amino)thieno[3,2-D]pyrimidine-7-carboxamide derivatives as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-08-07 | — | — | US | disclosed |
| US-10040803-B2 | 4-((2-acrylamidophenyl)amino)thieno[3,2-D]pyrimidine-7-carboxamide derivatives as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-08-07 | — | — | US | disclosed |
| US-20180148459-A1 | 4-((2-ACRYLAMIDOPHENYL)AMINO)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-05-31 | — | — | US | disclosed |
| US-20180148459-A1 | 4-((2-ACRYLAMIDOPHENYL)AMINO)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148459-A1 | 4-((2-ACRYLAMIDOPHENYL)AMINO)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CDK2, CDK2AP2, CDK2AP1 | FGFR4 1716/4885CSF1R 3614/4885RAF1 205/4885 |
| US-10040803-B2 | 4-((2-acrylamidophenyl)amino)thieno[3,2-D]pyrimidine-7-carboxamide derivatives as protein kinase inhibitors | CDK2, CDK2AP2, CDK2AP1 | FGFR4 1716/4885CSF1R 3614/4885RAF1 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.