Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 3/20 | 0.64 |
| ▸ | NPC1L1 | Q9UHC9 | 16/20 | 0.55 |
| ▸ | DRD5 | P21918 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187182 | 0.89 | DDR1 (0.70) | DDR1NPC1L1DRD5OPRM1OPRD1 | |
| SCHEMBL20187144 | 0.88 | NPC1L1 (0.66) | DDR1NPC1L1DRD5OPRM1OPRD1 | |
| SCHEMBL20822345 | 0.83 | DDR1 (0.65) | DDR1NPC1L1DRD5OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL20187231 | 0.83 | DDR1 (0.64) | DDR1NPC1L1DRD5OPRM1OPRD1 | |
| SCHEMBL20187190 | 0.82 | DDR1 (0.66) | DDR1NPC1L1 | |
| SCHEMBL20187150 | 0.81 | NPC1L1 (0.64) | DDR1NPC1L1 | |
| SCHEMBL1855447 | 0.80 | NPC1L1 (0.70) | DDR1NPC1L1OPRM1OPRK1 | |
| SCHEMBL8892630 | 0.80 | NPC1L1 (0.67) | DDR1NPC1L1OPRM1OPRK1 | |
| SCHEMBL5563023 | 0.79 | NPC1L1 (0.64) | DDR1NPC1L1OPRM1OPRD1OPRK1 | |
| SCHEMBL18373900 | 0.79 | DDR1 (1.00) | DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3317279-B1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-06-06 | — | — | US | disclosed |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMAN LA-ROCHE INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA-ROCHE INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | DDR1 1/4885NPC1L1 3430/4885DRD5 1915/4885 |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | DDR1 1/4885NPC1L1 3430/4885DRD5 1915/4885 |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | DDR1 1/4885NPC1L1 3430/4885DRD5 1915/4885 |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | DDR1 1/4885NPC1L1 3430/4885DRD5 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.