Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 10/20 | 0.62 |
| ▸ | NPC1L1 | Q9UHC9 | 7/20 | 0.54 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187172 | 0.88 | DDR1 (0.69) | DDR1BDKRB2OPRL1 | |
| SCHEMBL5563023 | 0.82 | NPC1L1 (0.64) | DDR1NPC1L1BDKRB2CCR5OPRL1 | |
| SCHEMBL20187236 | 0.80 | DDR1 (0.60) | DDR1NPC1L1BDKRB2OPRL1 | |
| SCHEMBL20187201 | 0.79 | DDR1 (0.60) | DDR1NPC1L1BDKRB2CCR5 | |
| SCHEMBL1855447 | 0.79 | NPC1L1 (0.70) | DDR1NPC1L1BDKRB2 | |
| SCHEMBL18601755 | 0.78 | NPC1L1 (0.59) | DDR1NPC1L1BDKRB2CCR5OPRL1 | |
| SCHEMBL318723 | 0.78 | NPC1L1 (0.59) | DDR1NPC1L1BDKRB2CCR5OPRL1 | |
| SCHEMBL20187174 | 0.78 | DDR1 (0.65) | DDR1NPC1L1BDKRB2CCR5 | |
| SCHEMBL20187155 | 0.78 | DDR1 (0.62) | DDR1NPC1L1BDKRB2 | |
| Water SCHEMBL5142065 | 0.78 | NPC1L1 (0.61) | DDR1NPC1L1BDKRB2CCR5OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849044-B | Triaza-spirodecanones as DDR1 inhibitors | 豪夫迈·罗氏有限公司 | 2021-06-25 | — | — | CN | disclosed |
| EP-3317279-B1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-06-06 | — | — | US | disclosed |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMAN LA-ROCHE INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA-ROCHE INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | DDR1 1/4885NPC1L1 3430/4885BDKRB2 1445/4885 |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | DDR1 1/4885NPC1L1 3430/4885BDKRB2 1445/4885 |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | DDR1 1/4885NPC1L1 3430/4885BDKRB2 1445/4885 |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | DDR1 1/4885NPC1L1 3430/4885BDKRB2 1445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.