Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016868 | 0.90 | PDE4B (0.59) | PDE4BPOLBJAK1JAK3 | |
| SCHEMBL2019367 | 0.89 | SMN1; SMN2 (0.58) | PDE4BSMN1; SMN2JAK1JAK3 | |
| SCHEMBL5672819 | 0.89 | PDE4B (0.59) | PDE4BPOLBJAK1JAK3 | |
| SCHEMBL2018427 | 0.89 | KDM4E (0.60) | PDE4BMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL2021218 | 0.88 | KDM4E (0.59) | PDE4BMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL2022521 | 0.88 | PDE4B (0.56) | PDE4BMAPTTP53POLBJAK1 | |
| SCHEMBL2021657 | 0.88 | PDE4B (0.56) | PDE4BPOLBJAK1JAK3 | |
| SCHEMBL2017069 | 0.86 | KDM4E (0.60) | PDE4BMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL2019790 | 0.85 | PDE4B (0.54) | PDE4BMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL2016289 | 0.84 | MEN1 (0.64) | PDE4BMAPTALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10568888-B2 | Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors | VTV THERAPEUTICS LLC (US) | 2020-02-25 | — | — | US | disclosed |
| US-20190336506-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | HIGH POINT PHARMACEUTICALS, LLC | 2019-11-07 | — | — | US | disclosed |
| US-10391097-B2 | Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors | VTV THERAPEUTICS LLC (US) | 2019-08-27 | — | — | US | disclosed |
| US-20180360839-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | TRANSTECH PHARMA, INC. | 2018-12-20 | — | — | US | disclosed |
| US-10085990-B2 | Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors | VTV THERAPEUTICS LLC (US) | 2018-10-02 | — | — | US | disclosed |
| US-20180071297-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | VTV THERAPEUTICS LLC | 2018-03-15 | — | — | US | disclosed |
| US-9833457-B2 | Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors | VTV THERAPEUTICS LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170252343-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | VTV THERAPEUTICS LLC | 2017-09-07 | — | — | US | disclosed |
| US-9687489-B2 | Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors | VTV THERAPEUTICS LLC (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160296526-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | VTV THERAPEUTICS LLC | 2016-10-13 | — | — | US | disclosed |
| US-20140371250-A1 | Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors | VTV THERAPEUTICS LLC | 2014-12-18 | — | — | US | disclosed |
| US-8853226-B2 | Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2244574-B1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF- SYNTHESIS AND AS PDE4 INHIBITORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2014-10-01 | — | — | EP | disclosed |
| US-8329715-B2 | Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-12-11 | — | — | US | disclosed |
| US-20120172381-A1 | Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-07-05 | — | — | US | disclosed |
| US-20110160234-A1 | Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-06-30 | — | — | US | disclosed |
| US-7964608-B2 | Tricyclic compounds as modulators of TNF-α synthesis | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-06-21 | — | — | US | disclosed |
| EP-2244574-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF- SYNTHESIS AND AS PDE4 INHIBITORS | High Point Pharmaceuticals, LLC (US) | 2010-11-03 | — | — | EP | disclosed |
| US-20100190808-A1 | Tricyclic Compounds As Modulators of TNF-alpha Synthesis | HIGH POINT PHARMACEUTICALS, LLC. (US) | 2010-07-29 | — | — | US | disclosed |
| WO-2009094528-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371250-A1 | Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors | PDE4A, PDE4B, TNF | PDE4B 2/4885MAPT 3323/4885ALDH1A1 887/4885 |
| US-20190336506-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | PDE4A, PDE4B, TNF | PDE4B 2/4885MAPT 2854/4885ALDH1A1 1159/4885 |
| US-20180360839-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE4C | PDE4B 2/4885MAPT 2672/4885ALDH1A1 680/4885 |
| US-20100190808-A1 | Tricyclic Compounds As Modulators of TNF-alpha Synthesis | TNF, PDE4A, PDE4B | PDE4B 3/4885MAPT 3265/4885ALDH1A1 738/4885 |
| US-10568888-B2 | Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors | PDE4A, PDE4B, TNF | PDE4B 2/4885MAPT 2854/4885ALDH1A1 1159/4885 |
| US-20110160234-A1 | Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors | PDE4A, PDE4B, TNF | PDE4B 2/4885MAPT 3323/4885ALDH1A1 887/4885 |
| US-20120172381-A1 | Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors | PDE4A, PDE4B, TNF | PDE4B 2/4885MAPT 3323/4885ALDH1A1 887/4885 |
| US-20180071297-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE4C | PDE4B 2/4885MAPT 2672/4885ALDH1A1 680/4885 |
| US-10085990-B2 | Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors | PDE4A, TNF, PDE4B | PDE4B 3/4885MAPT 2406/4885ALDH1A1 616/4885 |
| US-10391097-B2 | Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors | PDE4A, PDE4B, PDE4C | PDE4B 2/4885MAPT 2672/4885ALDH1A1 680/4885 |
| US-20170252343-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | TNF, PDE4A, PDE4B | PDE4B 3/4885MAPT 1928/4885ALDH1A1 988/4885 |
| US-20160296526-A1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS | PDE4A, TNF, PDE4B | PDE4B 3/4885MAPT 1995/4885ALDH1A1 1122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.