Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 4/20 | 0.74 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | GRAMD1A | Q96CP6 | 4/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 7/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22511903 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 | |
| SCHEMBL21106634 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 | |
| SCHEMBL22511880 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 | |
| SCHEMBL25123413 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 | |
| SCHEMBL20188589 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 | |
| SCHEMBL23884233 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 | |
| SCHEMBL25123821 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 | |
| SCHEMBL23884311 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 | |
| SCHEMBL21760067 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 | |
| SCHEMBL29990969 | 0.90 | CRBN (0.89) | CRBNDDB1HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544957-B1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA FARBER CANCER INST INC (US) | 2024-05-29 | — | — | EP | disclosed |
| US-20230131952-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230131952-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230131952-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-04-27 | — | — | US | disclosed |
| US-11578075-B2 | Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-11578075-B2 | Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-20210061811-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-03-04 | — | — | US | disclosed |
| US-20210061811-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-03-04 | — | — | US | disclosed |
| US-10899768-B2 | Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-01-26 | — | — | US | disclosed |
| EP-3544957-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2019-10-02 | — | — | EP | disclosed |
| US-20190263823-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-29 | — | — | US | disclosed |
| US-20190263823-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-29 | — | — | US | disclosed |
| WO-2018098280-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098280-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263823-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | MDM2, MAP2K2, TTK | CRBN 663/4885DDB1 755/4885HDAC1 991/4885 |
| US-20230131952-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | MDM2, MAP2K2, TTK | CRBN 663/4885DDB1 755/4885HDAC1 991/4885 |
| US-10899768-B2 | Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use | MDM2, MAP2K2, TTK | CRBN 663/4885DDB1 755/4885HDAC1 991/4885 |
| US-11578075-B2 | Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use | MDM2, MAP2K2, TTK | CRBN 663/4885DDB1 755/4885HDAC1 991/4885 |
| US-20210061811-A1 | DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | MDM2, MAP2K2, TTK | CRBN 663/4885DDB1 755/4885HDAC1 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.